Mechanisms of Antibiotic Resistance: QM/MM Modeling of the Acylation Reaction of a Class A β-Lactamase with Benzylpenicillin-Reference-Cited by-同舟云学术

Mechanisms of Antibiotic Resistance: QM/MM Modeling of the Acylation Reaction of a Class A β-Lactamase with Benzylpenicillin

Published:2005-03-01 Issue:12 Volume:127 Page:4454-4465
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Hermann Johannes C.¹,Hensen Christian¹,Ridder Lars¹,Mulholland Adrian J.¹,Höltje Hans-Dieter¹

Affiliation:

1. Contribution from the Institut für Pharmazeutische Chemie, Heinrich-Heine Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany, Molecular Design & Informatics, N.V. Organon, P.O. Box 20, 5340 BH Oss, The Netherlands, and School of Chemistry, University of Bristol, Bristol BS8 1TS, U.K.

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja044210d

Reference76 articles.

1. The Origin of Plagues: Old and New

2. Liability Bill Introduced in Congress

3. Inactivation of Antibiotics and the Dissemination of Resistance Genes

4. Catalytic properties of class A β-lactamases: efficiency and diversity

5. pKa, MM, and QM studies of mechanisms of β-lactamases and penicillin-binding proteins: Acylation step

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