Discovery of (2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a Selective α7 Nicotinic Acetylcholine Receptor Agonist, for the Treatment of Cognitive Disorders-Reference-Cited by-同舟云学术

Discovery of (2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a Selective α7 Nicotinic Acetylcholine Receptor Agonist, for the Treatment of Cognitive Disorders

Published:2012-11-13 Issue:22 Volume:55 Page:9793-9809
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mazurov Anatoly A.¹,Kombo David C.¹,Hauser Terry A.¹,Miao Lan¹,Dull Gary¹,Genus John F.¹,Fedorov Nikolai B.¹,Benson Lisa¹,Sidach Serguei¹,Xiao Yunde¹,Hammond Philip S.¹,James John W.¹,Miller Craig H.¹,Yohannes Daniel¹

Affiliation:

1. Targacept, Inc., Winston-Salem, North Carolina 27101-4165, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301048a

Reference83 articles.

1. Nicotinic receptors as targets for therapeutic discovery

2. A gating mechanism proposed from a simulation of a human 7 nicotinic acetylcholine receptor

3. Biochemical Characterization of a Novel Channel-Activating Site on Nicotinic Acetylcholine Receptors

4. Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

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