1. Cancer Research Centre and Department of Medical Biology of Laval University, Centre de Recherche de l'Hôtel-Dieu de Québec, 9 rue McMahon G1R 2J6 Québec, QC, Canada, and Department of Biochemistry, University of Toronto and Program in Cell Biology, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada