Purification of DMT-On Oligonucleotide by Simulated Moving-Bed (SMB) Chromatography

Author:

Schulte Michael1,Lühring Nadine1,Keil Andreas1,Sanghvi Yogesh S.1

Affiliation:

1. Merck KGaA, LSA R&D TS, Frankfurter Str. 250, D-64293 Darmstadt, Germany, and Rasayan, Inc., 2802 Crystal Ridge Road, Encinitas, California 92024-6615, U.S.A.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference11 articles.

1. Sanghvi, Y. S.; Andrade, M.; Deshmukh, R. R.; Holmberg, L.; Scozzari, A. N.; Cole, D. L. InManual of Antisense Methodology; Hartmann, G., Endres, S., Eds.; Kluwer Academic Publishers:  Germany, 1999; pp 3−23.

2. Deshmukh, R. R.; Leitch, W. E.; Sanghvi, Y. S.; Cole, D. L. InHandbook of Bioseparations; Ahuja, S., Ed.; Academic Press:  San Diego, CA, 2000; pp 512−534. Deshmukh, R. R.; Miller, J.; De Leon, P.; Leitch, W.; Cole, D. L.; Sanghvi, Y. S.Org. Process Res.Dev.2000,4, 205−213. Tugcu, N.; Deshmukh, R. R.; Sanghvi, Y. S.; Moore, J. A.; Cramer, S. A.J.Chromatogr.2001,923, 65−73. Lajmi, A.; Schwartz, L.; Sanghvi, Y. S.Org.Process Res.Dev.2004,8, 651−657. For a comprehensive review see:  Schulte, M. M.; Sanghvi, Y. S.Curr. Opin. Drug Discov. Dev.2004,7, 765−76.

3. Gilar, M.; Bouvier, E. S. P.J. Chromatogr., Sect.A2000,890, 167−177. Andrus, A.; Bloch, W. InHPLC of Macromolecules:  A Practical Approach, 2nd ed.; Oliver, R. W. A., Ed.; Oxford University Press:  New York, 1998; pp 141−170.

4. Simulated Moving Bed:  Basics and Applications; Nicoud, R. M., Ed.; INPL:  Nancy, France, 1993. Nicoud, R. M. InBioseparation andBioprocessing; Subramanian, G., Ed.; Wiley-VCH:  New York, 1998; pp 3−39.

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