The Rule of Five Revisited: Applying Log D in Place of Log P in Drug-Likeness Filters
Author:
Affiliation:
1. Advanced Chemistry Development, Inc. (ACD/Labs), 110 Yonge Street, 14th Floor, Toronto, ON, Canada, M5C 1T4
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/mp0700209
Reference14 articles.
1. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
2. A Comparison of Physiochemical Property Profiles of Development and Marketed Oral Drugs
3. Virtual Screening in Lead Discovery: A Viewpoint
4. Drug-like properties and the causes of poor solubility and poor permeability
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