(±)-trans-2-[3-Methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a Potent Dual 5-Lipoxygenase Inhibitor and Platelet-Activating Factor Receptor Antagonist-Reference-Cited by-同舟云学术

(±)-trans-2-[3-Methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a Potent Dual 5-Lipoxygenase Inhibitor and Platelet-Activating Factor Receptor Antagonist

Published:1998-04-29 Issue:11 Volume:41 Page:1970-1979
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cai Xiong¹,Scannell Ralph T.¹,Yaeger David¹,Hussoin Md. Sajjat¹,Killian David B.¹,Qian Changgeng¹,Eckman Joseph¹,Hwang San-Bao¹,Libertine-Garahan Lynn¹,Yeh C. Grace¹,Ip Stephen H.¹,Shen T. Y.¹

Affiliation:

1. CytoMed, Inc., 840 Memorial Drive, Cambridge, Massachusetts 02139, and Department of Chemistry, University of Virginia, Charlottesville, Virginia 22903

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980046r

Reference24 articles.

1. 5-Lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors

2. Severe Streptococcal Axillary Lymphadenitis

3. The Role of Leukotrienes in Inflammation

4. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

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