Biphenylsulfonamide Endothelin Receptor Antagonists. 4. Discovery of N-[[2‘-[[(4,5-Dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1‘-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), A Highly Potent and Orally Active ETA Selective Antagonist-Reference-Cited by-同舟云学术

Biphenylsulfonamide Endothelin Receptor Antagonists. 4. Discovery of N-[[2‘-[[(4,5-Dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1‘-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), A Highly Potent and Orally Active ETA Selective Antagonist

Published:2002-11-26 Issue:1 Volume:46 Page:125-137
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Murugesan Natesan¹,Gu Zhengxiang¹,Spergel Steven¹,Young Marian¹,Chen Ping¹,Mathur Arvind¹,Leith Leslie¹,Hermsmeier Mark¹,Liu Eddie C.-K.¹,Zhang Rongan¹,Bird Eileen¹,Waldron Tom¹,Marino Anthony¹,Koplowitz Barry¹,Humphreys W. Griffith¹,Chong Saeho¹,Morrison Richard A.¹,Webb Maria L.¹,Moreland Suzanne¹,Trippodo Nick¹,Barrish Joel C.¹

Affiliation:

1. Departments of Chemistry, Cardiovascular Agents, Cardiovascular Biochemistry and Pharmacology, Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-5400

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm020289q

Reference24 articles.

1. A novel potent vasoconstrictor peptide produced by vascular endothelial cells

2. The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

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