Pragmatic Approaches to Determine the Exposures of Drug Metabolites in Preclinical and Clinical Subjects in the MIST Evaluation of the Clinical Development Phase-Reference-Cited by-同舟云学术

Pragmatic Approaches to Determine the Exposures of Drug Metabolites in Preclinical and Clinical Subjects in the MIST Evaluation of the Clinical Development Phase

Published:2014-03-24 Issue:4 Volume:27 Page:601-610
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Haglund Johanna¹,Halldin Magnus M.¹,Brunnström Åsa¹,Eklund Göran¹,Kautiainen Antti¹,Sandholm Anna¹,Iverson Suzanne L.¹

Affiliation:

1. AstraZeneca R&D, DMPK Södertälje, SE-151 85 Södertälje, Sweden

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx400449z

Reference47 articles.

1. Drug Metabolites in Safety Testing

2. SEEING THROUGH THE MIST: ABUNDANCE VERSUS PERCENTAGE. COMMENTARY ON METABOLITES IN SAFETY TESTING

3. Safety Assessment of Stable Drug Metabolites

4. A Regulatory Perspective on Issues and Approaches in Characterizing Human Metabolites

5. Safety Assessment of Drug Metabolites: Characterization of Chemically Stable Metabolites

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