1. Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel, Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, California, Graduate School Neurosciences Amsterdam, Institute of Neuroscience Vrije Universiteit, Faculty of Biology, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands, and Department of Cell & Animal Biology, Silberman Institute of Life Sciences, Hebrew University of Jerusalem, 91904 Jerusalem, Israel