Synthesis of C11-Desmethoxy Soraphen A1α: A Natural Product Analogue That Inhibits Acetyl-CoA Carboxylase-Reference-Cited by-同舟云学术

Synthesis of C11-Desmethoxy Soraphen A1α: A Natural Product Analogue That Inhibits Acetyl-CoA Carboxylase

Published:2013-11-06 Issue:12 Volume:4 Page:1244-1248
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Canterbury Daniel P.¹,Scott Kristen E. N.²,Kubo Ozora¹,Jansen Rolf³,Cleveland John L.²,Micalizio Glenn C.¹

Affiliation:

1. Department of Chemistry, The Scripps Research Institute, Jupiter, Florida 33458, United States

2. Department of Cancer Biology, The Scripps Research Institute, Jupiter, Florida 33458, United States

3. Department of Microbial Drugs, Helmholtz Centre for Infection Research, Braunschweig, Germany

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml400377p

Reference39 articles.

1. Reichenbach, H.; Höfle, G.; Augustiniak, H.; Bedorf, N.; Forche, E.; Gerth, K.; Irschik, H.; Jansen, R.; Kunze, B.; Sasse, F.; Steinmetz, H.; Trowitzch-Kienast, W.; Pachlatko, J. P.EP 282455A2, 1988.

2. Antibiotics from Gliding Bacteria, LIV. Isolation and Structure Elucidation of Soraphen A1α, a Novel Antifungal Macrolide fromSorangium cellulosum

3. The soraphens: A family of novel antifungal compounds from Sorangium cellulosum (myxobacteria). I. Soraphen A1.ALPHA.: Fermentation, isolation, biological properties.

4. Identification of the yeast ACC1 gene product (acetyl-CoA carboxylase) as the target of the polyketide fungicide soraphen A

5. A Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme A Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Algorithm-aided engineering of aliphatic halogenase WelO5* for the asymmetric late-stage functionalization of soraphens;Nature Communications;2022-01-18

2. Total Synthesis of the Acetyl CoA Carboxylase Inhibitor Soraphen A: Asymmetric Tsuji Reduction Enables Successive Olefin Metathesis;Journal of the American Chemical Society;2022-01-10

3. Recent development in acetyl-CoA carboxylase inhibitors and their potential as novel drugs;Future Medicinal Chemistry;2020-03

4. Acetyl-CoA carboxylase (ACC) as a therapeutic target for metabolic syndrome and recent developments in ACC1/2 inhibitors;Expert Opinion on Investigational Drugs;2019-08-29

5. The intriguing chemistry and biology of soraphens;Natural Product Reports;2019