Discovery of Novel Allosteric Mitogen-Activated Protein Kinase Kinase (MEK) 1,2 Inhibitors Possessing Bidentate Ser212 Interactions-Reference-Cited by-同舟云学术

Discovery of Novel Allosteric Mitogen-Activated Protein Kinase Kinase (MEK) 1,2 Inhibitors Possessing Bidentate Ser212 Interactions

Published:2012-05-03 Issue:10 Volume:55 Page:4594-4604
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Heald Robert A.¹,Jackson Philip¹,Savy Pascal¹,Jones Mark¹,Gancia Emanuela¹,Burton Brenda¹,Newman Richard¹,Boggs Jason²,Chan Emily²,Chan Jocelyn²,Choo Edna²,Merchant Mark²,Rudewicz Patrick²,Ultsch Mark²,Wiesmann Christian²,Yue Qin²,Belvin Marcia²,Price Steve¹

Affiliation:

1. Argenta, 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, U.K.

2. Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm2017094

Reference33 articles.

1. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

2. Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors