Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses

Author:

Weil Tatjana1ORCID,Kirupakaran Abbna2,Le My-Hue2,Rebmann Philipp2,Mieres-Perez Joel3,Issmail Leila4,Conzelmann Carina1,Müller Janis A.5,Rauch Lena1,Gilg Andrea1,Wettstein Lukas1,Groß Rüdiger1ORCID,Read Clarissa67,Bergner Tim6,Pålsson Sandra Axberg8,Uhlig Nadja4ORCID,Eberlein Valentina4,Wöll Heike2,Klärner Frank-Gerrit2,Stenger Steffen9,Kümmerer Beate M.1011,Streeck Hendrik1011,Fois Giorgio12,Frick Manfred12ORCID,Braubach Peter13,Spetz Anna-Lena8,Grunwald Thomas4,Shorter James14ORCID,Sanchez-Garcia Elsa3ORCID,Schrader Thomas2ORCID,Münch Jan1ORCID

Affiliation:

1. Institute of Molecular Virology, Ulm University Medical Center, Ulm89081, Germany

2. Faculty of Chemistry, University of Duisburg-Essen, Essen45117, Germany

3. Computational Biochemistry, University of Duisburg-Essen, Essen45117, Germany

4. Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig04103, Germany

5. Institute of Virology, Philipps University of Marburg, Marburg35043, Germany

6. Central Facility for Electron Microscopy, Ulm University, Ulm89081, Germany

7. Institute of Virology, Ulm University Medical Center, Ulm89081, Germany

8. Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm10691, Sweden

9. Institute for Microbiology and Hygiene, Ulm University Medical Center, Ulm89081, Germany

10. Institute of Virology, Medical Faculty, University of Bonn, Bonn53127, Germany

11. German Centre for Infection Research (DZIF), partner site Bonn-Cologne, Bonn53127, Germany

12. Institute of General Physiology, Ulm University, Ulm89081, Germany

13. Institute of Pathology, Hannover Medical School (MHH), Hannover30625, Germany

14. Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia19104, United States

Funder

Deutsche Forschungsgemeinschaft

Horizon 2020 Framework Programme

Publisher

American Chemical Society (ACS)

Subject

General Medicine

Reference47 articles.

1. Efficacy of Remdesivir in COVID-19

2. EUA 105 Pfizer Paxlovid LOA (12222021) | Enhanced Reader moz-extension://d7e179ea-8b25–4590-95dc-ed847a8038e3/enhanced-reader.html?openApp&pdf=https%3A%2F%2Fwww.fda.gov%2Fmedia%2F155049%2Fdownload (accessed Jan 17, 2022).

3. Efficacy of tocilizumab treatment in severely ill COVID-19 patients

4. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

5. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

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