Pyrazolo[1,5-a]-1,3,5-triazine as a Purine Bioisostere: Access to Potent Cyclin-Dependent Kinase Inhibitor (R)-Roscovitine Analogue-Reference-Cited by-同舟云学术

Pyrazolo[1,5-a]-1,3,5-triazine as a Purine Bioisostere: Access to Potent Cyclin-Dependent Kinase Inhibitor (R)-Roscovitine Analogue

Published:2009-01-07 Issue:3 Volume:52 Page:655-663
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Popowycz Florence¹,Fournet Guy¹,Schneider Cédric¹,Bettayeb Karima¹,Ferandin Yoan¹,Lamigeon Cyrile¹,Tirado Oscar M.¹,Mateo-Lozano Silvia¹,Notario Vicente¹,Colas Pierre¹,Bernard Philippe¹,Meijer Laurent¹,Joseph Benoît¹

Affiliation:

1. Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, UMR-CNRS 5246, Laboratoire de Chimie Organique 1, Université de Lyon, Université Claude Bernard-Lyon 1, Bâtiment Curien, 43 Boulevard du 11 Novembre 1918, F-69622 Villeurbanne, France, CNRS, “Protein Phosphorylation & Human Disease” Group, Station Biologique, B.P. 74, 26682 Roscoff, France, Laboratory of Experimental Carcinogenesis, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3970 Reservoir Road NW,...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801340z

Reference42 articles.

1. Cyclin-Dependent Kinase Pathways As Targets for Cancer Treatment

2. Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF

3. A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival

4. Cdk5 deregulation in the pathogenesis of Alzheimer's disease

5. CDKs: taking on a role as mediators of dopaminergic loss in Parkinson's disease

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