A Practical Kilogram-Scale Process to a Milnacipran Analogue, N,N-Diallyl (1R, 2R)-2-(Aminomethyl)-1-(2-thienyl)cyclopropanecarboxamide
Author:
Affiliation:
1. Lab of Biocatalysis, Hangzhou Normal University, Science and Technology Park, 1378 West Wenyi Road, Hangzhou 311121, China
2. Agno Pharma, A5-401, BioBay, 218 Xinghu Street, Suzhou Industrial Park, 215000 China
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op3001542
Reference16 articles.
1. Milnacipran: A Dual Norepinephrine and Serotonin Reuptake Pump Inhibitor
2. SNRIs: The Pharmacology, Clinical Efficacy, and Tolerability in Comparison with Other Classes of Antidepressants
3. Serotonin and noradrenaline reuptake inhibitors in animal models of pain
4. Characterization of Thien-2-yl 1S,2R-Milnacipran Analogues as Potent Norepinephrine/Serotonin Transporter Inhibitors for the Treatment of Neuropathic Pain
5. Synthesis of (+)- and (−)-milnaciprans and their conformationally restricted analogs
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1. Enantioselective synthesis of a cyclobutane analogue of Milnacipran;Organic Chemistry Frontiers;2017
2. Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals;Organic Process Research & Development;2016-02-05
3. Hydrazoic Acid and Azides;Ullmann's Encyclopedia of Industrial Chemistry;2015-09-30
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