Design, Synthesis, and Pharmacological Evaluation of N-Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase-4 Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, and Pharmacological Evaluation of N-Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase-4 Inhibitors

Published:2012-08-30 Issue:17 Volume:55 Page:7525-7545
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kümmerle Arthur E.¹²,Schmitt Martine³,Cardozo Suzana V. S.⁴⁵,Lugnier Claire⁶,Villa Pascal⁷,Lopes Alexandra B.¹²,Romeiro Nelilma C.⁸,Justiniano Hélène⁶,Martins Marco A.⁴,Fraga Carlos A. M.¹⁵,Bourguignon Jean-Jacques³,Barreiro Eliezer J.¹

Affiliation:

1. Laboratório de Avaliacão e Síntese de Substâncias Bioativas (LASSBio), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 68023, RJ 21944-971, Brazil

2. Programa de Pós-Graduação em Química, Instituto de Química, Universidade Federal do Rio de Janeiro, 21941-902, Rio de Janeiro, RJ, Brazil

3. Laboratoire d’Innovation Thérapeutique, UMR7200, CNRS, Université de Strasbourg, Faculté de Pharmacie, 74 Route du Rhin, 67400 Illkirch-Graffenstaden, France

4. Laboratório de Inflamação, Departamento de Fisiologia e Farmacodinâmica, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brazil

5. Programa de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, Brazil

6. Biophotonique et Pharmacologie, UMR7213, CNRS, Université de Strasbourg, Faculté de Pharmacie, 74 Route du Rhin, 67400 Illkirch-Graffenstaden, France

7. Plate-forme de Chimie Biologie Integrative de Strasbourg (PCBIS), UMR3286, CNRS, Université de Strasbourg, Ecole Supérieur de Biotechnologie et Faculté de Pharmacie, Boulevard Sebastien Brant, 67412 Illkirch-Graffenstaden, France

8. Universidade Federal do Rio de Janeiro (UFRJ)-Macaé-Rua Aluísio da Silva Gomes, 50 Granja dos Cavaleiros, 27930-560 Rio de Janeiro, RJ, Brazil

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300514y

Reference96 articles.

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4. Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments

5. Cyclic nucleotide phosphodiesterases: Relating structure and function

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