Unleashing the Power of Evolution in Xylanase Engineering: Investigating the Role of Distal Mutation Regulation

Author:

Wu Ya12,Yang Yu3,Lu Gen12,Xiang Wan-Lu3,Sun Tian-Yu4ORCID,Chen Ke-Wei5,Lv Xiang6,Gui Yi-Fan12,Zeng Rui-Qi1,Du Yi-Kai1,Fu Chun-Hua12,Huang Jian-Wen3,Chen Chun-Chi37,Guo Rey-Ting37ORCID,Yu Long-Jiang12ORCID

Affiliation:

1. Institute of Resource Biology and Biotechnology, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, China

2. Key Laboratory of Molecular Biophysics, Ministry of Education, 1037 Luoyu Road, Wuhan 430074, China

3. State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Hongshan Laboratory, Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, Hubei Key Laboratory of Industrial Biotechnology, School of Life Sciences, Hubei University, Wuhan 430062, China

4. Shenzhen Bay Laboratory, Shenzhen 518132, China

5. Lab of Computational Chemistry and Drug Design, State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China

6. Ministry of Education Key Laboratory of Industrial Biotechnology, School of Biotechnology, Jiangnan University, Wuxi 214122, China

7. Zhejiang Key Laboratory of Medical Epigenetics, Department of Immunology and Pathogen Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou 311121, China

Funder

National Key Research and Development Program of China

Huazhong University of Science and Technology

Hongshan Laboratory

Publisher

American Chemical Society (ACS)

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