Novel Pyrido[4,3-<i>d</i>]pyrimidine Derivatives as Potential Sterol 14α-Demethylase Inhibitors: Design, Synthesis, Inhibitory Activity, and Molecular Modeling-Reference-Cited by-同舟云学术

Novel Pyrido[4,3-d]pyrimidine Derivatives as Potential Sterol 14α-Demethylase Inhibitors: Design, Synthesis, Inhibitory Activity, and Molecular Modeling

Published:2024-05-17 Issue:21 Volume:72 Page:12260-12269
ISSN:0021-8561
Container-title:Journal of Agricultural and Food Chemistry
language:en
Short-container-title:J. Agric. Food Chem.

Author:

Yan Yingkun¹^ORCID,Xie Xiansong¹,Jiang Wenjing²,Bao Ailing¹,Deng Ziquan¹,Wang Deyuan¹,Wang Jingwen¹,Li Weiyi¹^ORCID,Tang Xiaorong¹^ORCID

Affiliation:

1. School of Science, Xihua University, Chengdu 610039, PR China

2. Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, PR China

Funder

Xihua University

Chengdu Science and Technology Bureau

Chunhui Project Foundation of the Education Department of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jafc.3c09543

Reference48 articles.

1. Sterol 14α-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms

2. Structural basis for conservation in the CYP51 family

3. Sterol 14α-demethylase, an abundant and essential mixed-function oxidase

4. Structural Insights into Inhibition of Sterol 14α-Demethylase in the Human Pathogen Trypanosoma cruzi

5. Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis

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