<i>Ganoderma lucidum</i> Polysaccharide Supplementation Significantly Activates T-Cell-Mediated Antitumor Immunity and Enhances Anti-PD-1 Immunotherapy Efficacy in Colorectal Cancer-Reference-Cited by-同舟云学术

Ganoderma lucidum Polysaccharide Supplementation Significantly Activates T-Cell-Mediated Antitumor Immunity and Enhances Anti-PD-1 Immunotherapy Efficacy in Colorectal Cancer

Published:2024-05-16 Issue:21 Volume:72 Page:12072-12082
ISSN:0021-8561
Container-title:Journal of Agricultural and Food Chemistry
language:en
Short-container-title:J. Agric. Food Chem.

Author:

Li Wenshuai¹²,Zhou Qi²,Lv Bin²,Li Na¹^ORCID,Bian Xiqing¹,Chen Lirong²,Kong Mingjia²,Shen Yuru²,Zheng Wanwei²,Zhang Jun²,Luo Feifei²,Luo Zhongguang²,Liu Jie²³^ORCID,Wu Jian-Lin¹^ORCID

Affiliation:

1. State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macao 999078, China

2. Department of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China

3. Department of Digestive Diseases, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, China

Funder

Science and Technology Commission of Shanghai Municipality

Fundo para o Desenvolvimento das Ci?ncias e da Tecnologia

Beijing Health Alliance Charitable Foundation

Macao Young Scholars Program

Shanghai Sailing Program

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jafc.3c08385

Reference57 articles.

1. A novel promising neuroprotective agent: Ganoderma lucidum polysaccharide

2. Ganoderma lucidum polysaccharide extract inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation and function by inducing microRNA-125b

3. Effective cancer immunotherapy by Ganoderma lucidum polysaccharide-gold nanocomposites through dendritic cell activation and memory T cell response

4. Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation

5. Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon

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