Isothermal Compressibility Perturbation as a Protein Design Principle for T1 Lipase Stability–Activity Trade-Off Counteracting
Author:
Affiliation:
1. Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu 214122, China
2. Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
Funder
Ministry of Science and Technology of the People's Republic of China
China Postdoctoral Science Foundation
Natural Science Foundation of Jiangsu Province
Central University Basic Research Fund of China
Jiangsu Science and Technology Department
Publisher
American Chemical Society (ACS)
Subject
General Agricultural and Biological Sciences,General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jafc.3c01684
Reference42 articles.
1. Protein stability promotes evolvability
2. Missense meanderings in sequence space: a biophysical view of protein evolution
3. Review: Protein function at thermal extremes: balancing stability and flexibility
4. Defying the activity–stability trade-off in enzymes: taking advantage of entropy to enhance activity and thermostability
5. Reduced Enzyme Dynamics upon Multipoint Covalent Immobilization Leads to Stability-Activity Trade-off
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