Affinity Crystallography Reveals Binding of Pomegranate Juice Anthocyanins at the Inhibitor Site of Glycogen Phosphorylase: The Contribution of a Sugar Moiety to Potency and Its Implications to the Binding Mode
Author:
Affiliation:
1. Department of Biochemistry and Biotechnology, University of Thessaly, Biopolis 41500, Larisa, Greece
2. Department of Food Science and Human Nutrition, Agricultural University of Athens, Athens 118 55, Greece
Funder
European Commission
Greece
National Research Infrastructures on integrated biology, drug screening efforts and drug target functional characterization
Publisher
American Chemical Society (ACS)
Subject
General Agricultural and Biological Sciences,General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jafc.0c04205
Reference63 articles.
1. Glycogen Phosphorylase as a Molecular Target for Type 2 Diabetes Therapy
2. Targeting hepatic glucose metabolism in the treatment of type 2 diabetes
3. Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis
4. Physiological Control of Liver Glycogen Metabolism: Lessons from Novel Glycogen Phosphorylase Inhibitors
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