Magnoflorine Ameliorates Chronic Kidney Disease in High-Fat and High-Fructose-Fed Mice by Promoting Parkin/PINK1-Dependent Mitophagy to Inhibit NLRP3/Caspase-1-Mediated Pyroptosis

Author:

Cheng Ye1,Lu Zhengjie2,Mao Tongyun3,Song Yingying4,Qu Yaqin4,Chen Xin4,Chen Kaiqi5,Liu Kexin6,Zhang Cong7ORCID

Affiliation:

1. Pharmaceutical Department, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430079, China

2. Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430072, China

3. Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China

4. Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China

5. Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

6. Department of Pharmacy, Zhongnan Hospital of Wuhan University, Wuhan 430072, China

7. College of Basic Medical Sciences, China Three Gorges University, Yichang 443002, China

Funder

Natural Science Foundation of Hubei Province

National Natural Science Foundation of China

Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine, Hubei University of Chinese Medicine

Publisher

American Chemical Society (ACS)

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