Biotransformation of the Antibiotic Danofloxacin by Xylaria longipes Leads to an Efficient Reduction of Its Antibacterial Activity

Author:

Rusch Marina1,Kauschat Annika1,Spielmeyer Astrid1,Römpp Andreas2,Hausmann Heike3,Zorn Holger1,Hamscher Gerd1

Affiliation:

1. Institute of Food Chemistry and Food Biotechnology, Justus Liebig University Giessen, Heinrich-Buff-Ring 58, 35392 Giessen, Germany

2. Institute of Inorganic and Analytical Chemistry, Justus Liebig University Giessen, Schubertstrasse 60, 35392 Giessen, Germany

3. Institute of Organic Chemistry, Justus Liebig University Giessen, Heinrich-Buff-Ring 58, 35392 Giessen, Germany

Funder

Deutsche Forschungsgemeinschaft

Hessisches Ministerium f?r Wissenschaft und Kunst

Publisher

American Chemical Society (ACS)

Subject

General Agricultural and Biological Sciences,General Chemistry

Reference36 articles.

1. Mode of Action of Fluoroquinolones

2. Synthesis and structure-activity relationships of 7-diazabicycloalkylquinolones, including danofloxacin, a new quinolone antibacterial agent for veterinary medicine

3. Federal Office for Consumer Protection and Food Safety.Dritte Datenerhebung zur Antibiotikaabgabe in der Tiermedizin;http://www.bvl.bund.de/DE/08_PresseInfothek/01_FuerJournalisten/01_Presse_und_Hintergrundinformationen/05_Tierarzneimittel/2014/2014_08_01_pi_Abgabemengen_korrigiert_29_08_2014.html;jsessionid=CA13CE12470E7E50A9FD2FEB86C112C9.2_cid322(accessed May 2015).

4. World Health Organization. Critically important antimicrobialsfor human medicine; http://www.who.int/foodsafety/publications/antimicrobials-third/en/(accessed May 2015).

5. Analysis of fluoroquinolones in biological fluids by high-performance liquid chromatography

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