Discovery of Novel (5-Mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)methyl Phenyl Carbamate as a Potent Phytoene Desaturase Inhibitor through Scaffold Hopping and Linker Modification

Author:

Zhang Di12,Wang Chunxue12,Zhang Yichi12,Yu Zhilei12,Hong Zeyu12,Jia Ding12,Ma Dejun12ORCID,Gu Yucheng3ORCID,Xu Han12,Xi Zhen12ORCID

Affiliation:

1. National Pesticide Engineering Research Center (Tianjin), Department of Chemical Biology, State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China

2. Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, P. R. China

3. Syngenta Jealott’s Hill International Research Centre, Bracknell RG42 6EY, U.K.

Funder

Nankai University

National Key Research and Development Program of China

Tianjin Municipal Science and Technology Program

National Natural Science Foundation of China

Frontiers Science Center for New Organic Matter, Nankai University

Publisher

American Chemical Society (ACS)

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