Synthesis and Structure–Activity Relationships of 5,6,7-Substituted Pyrazolopyrimidines: Discovery of a Novel TSPO PET Ligand for Cancer Imaging-Reference-Cited by-同舟云学术

Synthesis and Structure–Activity Relationships of 5,6,7-Substituted Pyrazolopyrimidines: Discovery of a Novel TSPO PET Ligand for Cancer Imaging

Published:2013-04-03 Issue:8 Volume:56 Page:3429-3433
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tang Dewei¹²,McKinley Eliot T.¹³,Hight Matthew R.¹⁴,Uddin Md. Imam¹⁵,Harp Joel M.⁶⁷,Fu Allie¹,Nickels Michael L.¹⁵,Buck Jason R.¹⁵,Manning H. Charles¹²³⁵⁸

Affiliation:

1. Vanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University Medical Center, Nashville, Tennessee, United States

2. Program in Chemical and Physical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States

3. Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, United States

4. Interdisciplinary Materials Science Program, Department of Physics & Astronomy, Vanderbilt University, Nashville, Tennessee, United States

5. Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, United States

6. Department of Biochemistry, Vanderbilt University Medical Center, Nashville, Tennessee, United States

7. Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States

8. Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4001874

Reference18 articles.

1. Targeted Imaging of Colonic Tumors in Smad3−/− Mice Discriminates Cancer and Inflammation

2. Molecular Imaging of the Translocator Protein (TSPO) in a Pre-Clinical Model of Breast Cancer

3. Targeted Molecular Imaging Agents for Cellular-Scale Bimodal Imaging

4. Quantitative Preclinical Imaging of TSPO Expression in Glioma Using N,N-Diethyl-2-(2-(4-(2-18F-Fluoroethoxy)Phenyl)-5,7-Dimethylpyrazolo[1,5-a]Pyrimidin-3-yl)Acetamide

5. Quantitative, Preclinical PET of Translocator Protein Expression in Glioma Using 18F-N-Fluoroacetyl-N-(2,5-Dimethoxybenzyl)-2-Phenoxyaniline

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