The Synthesis of Bromomethyltrifluoroborates through Continuous Flow Chemistry

Author:

Broom Toby1,Hughes Mark2,Szczepankiewicz Bruce G.3,Ace Karl2,Hagger Ben2,Lacking Gary,Chima Ranjit2,Marchbank Graeme2,Alford Gareth2,Evans Paul2,Cunningham Christopher4,Roberts John C.3,Perni Robert B.3,Berry Malcolm2,Rutter Andrew2,Watson Simon A.2

Affiliation:

1. GlaxoSmithKline, Research and Development, 709 Swedeland Road, King of Prussia, Pennsylvania 19406-0939, United States

2. GlaxoSmithKline, Research and Development, Gunnelswood Road, Stevenage SG1 2NY, United Kingdom

3. Sirtris, a GSK Company, 200 Technology Square, Suite 300, Cambridge, Massachusetts 02139, United States

4. Glaxo Operations UK, Ltd., Drug Manufacturer, Priory Street, Ware, Hertfordshire SG12 0DJ, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference25 articles.

1. aSuzuki, A.Cross-coupling Reactions of Organoboron Compounds with Organic Halides. InMetal-Catalyzed Cross-Coupling Reactions;Diederich, F. and Stang, P. J., Eds.Wiley-VCH Verlag GmbH:Weinheim, Germany, 1998; pp49–97.

2. Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds

3. Recent advances in the cross-coupling reactions of organoboron derivatives with organic electrophiles, 1995–1998

4. Facile Synthesis of Highly Functionalized Ethyltrifluoroborates

5. Synthesis of Functionalized Organotrifluoroborates via the 1,3-Dipolar Cycloaddition of Azides

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