Synthesis and Biological Evaluation of 3-Biphenyl-4-yl-4-phenyl-4H-1,2,4-triazoles as Novel Glycine Transporter 1 Inhibitors-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of 3-Biphenyl-4-yl-4-phenyl-4H-1,2,4-triazoles as Novel Glycine Transporter 1 Inhibitors

Published:2010-12-09 Issue:1 Volume:54 Page:387-391
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sugane Takashi¹,Tobe Takahiko¹,Hamaguchi Wataru¹,Shimada Itsuro¹,Maeno Kyoichi¹,Miyata Junji¹,Suzuki Takeshi¹,Kimizuka Tetsuya²,Kohara Atsuyuki¹,Morita Takuma³,Doihara Hitoshi¹,Saita Kyouko¹,Aota Masaki¹,Furutani Masako¹,Shimada Yoshiaki¹,Hamada Noritaka¹,Sakamoto Shuichi⁴,Tsukamoto Shin-ichi¹

Affiliation:

1. Drug Discovery Research, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan

2. Intellectual Property, Astellas Pharma Inc., 2-3-11, Nihonbashi-Honcho, Chuo-ku, Tokyo 103-8411, Japan

3. Astellas Research Technologies Co., Ltd., 21, Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan

4. Technology, Astellas Pharma Inc., 3-17-1, Hasune, Itabashi, Tokyo 174-8612, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101031u

Reference19 articles.

1. Neutral amino acid transport in epithelial cells and its malfunction in Hartnup disorder

2. Glycine Transporter 1 Inhibitors and Modulation of NMDA Receptor-Mediated Excitatory Neurotransmission

3. Potentiation of the NMDA receptor in the treatment of schizophrenia: focused on the glycine site

4. Glutamate receptor function in learning and memory

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