A New Synthesis of Functionalized 2-Alkylidenetetrahydro-5-furanones by Tandem Alkylation and Translactonization Reactions of 5(4H)-Oxazolones-Reference-Cited by-同舟云学术

A New Synthesis of Functionalized 2-Alkylidenetetrahydro-5-furanones by Tandem Alkylation and Translactonization Reactions of 5(4H)-Oxazolones

Published:1996-01-01 Issue:5 Volume:61 Page:1854-1856
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Cannella Roberta¹,Clerici Francesca¹,Gelmi Maria L.¹,Penso Michele¹,Pocar Donato¹

Affiliation:

1. Istituto di Chimica Organica, Facoltà di Farmacia, Università di Milano, Via Venezian 21, I-20133 Milano, Italy and Centro C.N.R.-C.S.S.S. Speciali Sistemi Organici, Via Golgi 19, I-20133 Milano, Italy

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo951213n

Reference19 articles.

1. Synthesis of halo enol lactones. Mechanism-based inactivators of serine proteases

2. Synthesis of five-membered halo enol lactone analogs of .alpha.-amino acids: potential protease suicide substrates

3. Analysis of the interaction of haloenol lactone suicide substrates with .alpha.-chymotrypsin using computer graphics and molecular mechanics

4. Enol lactone inhibitors of serine proteases. The effect of regiochemistry on the inactivation behavior of phenyl-substituted (halomethylene)tetra- and dihydrofuranones and tetrahydropyranones toward .alpha.-chymotrypsin: stable acyl enzyme intermediate

5. Alternate substrate inhibitors of an .alpha.-chymotrypsin: enantioselective interaction of aryl-substituted enol lactones

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