Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase-Reference-Cited by-同舟云学术

Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase

Published:2008-04-22 Issue:10 Volume:51 Page:2879-2882
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Albrecht Brian K.¹,Harmange Jean-Christophe¹,Bauer David¹,Berry Loren¹,Bode Christiane¹,Boezio Alessandro A.¹,Chen April¹,Choquette Deborah¹,Dussault Isabelle¹,Fridrich Cary¹,Hirai Satoko¹,Hoffman Doug¹,Larrow Jay F.¹,Kaplan-Lefko Paula¹,Lin Jasmine¹,Lohman Julia¹,Long Alexander M.¹,Moriguchi Jodi¹,O’Connor Anne¹,Potashman Michele H.¹,Reese Monica¹,Rex Karen¹,Siegmund Aaron¹,Shah Kavita¹,Shimanovich Roman¹,Springer Stephanie K.¹,Teffera Yohannes¹,Yang Yajing¹,Zhang Yihong¹,Bellon Steven F.¹

Affiliation:

1. Amgen Inc., One Kendall Square, Building 1000, Cambridge, Massachusetts 02139, and Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800043g

Reference12 articles.

1. Tyrosine kinase receptor indistinguishable from the c-met protein

2. Met, metastasis, motility and more

3. Hereditary Papillary Renal Carcinoma Type I

4. MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling

5. Targeting Tyrosine Kinases in Cancer: The Second Wave

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