Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H-Reference-Cited by-同舟云学术

Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

Published:2011-06-02 Issue:13 Volume:54 Page:4462-4473
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chung Suhman¹,Himmel Daniel M.²,Jiang Jian-Kang³,Wojtak Krzysztof²,Bauman Joseph D.²,Rausch Jason W.¹,Wilson Jennifer A.⁴,Beutler John A.⁴,Thomas Craig J.³,Arnold Eddy²,Le Grice Stuart F.J.¹

Affiliation:

1. RT Biochemistry Section, HIV Drug Resistance Program, National Cancer Institute—Frederick, Frederick, Maryland 21702, United States

2. Center for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States

3. NIH Chemical Genomics Center, Rockville, Maryland 20850, United States

4. Molecular Discovery Program, National Cancer Institute—Frederick, Frederick, Maryland 21702, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm2000757

Reference53 articles.

1. Champoux, J. J.Roles of Ribonuclease H in Reverse Transcription;Cold Spring Harbor Laboratory Press:Cold Spring Harbor, NY, 1993; pp103–118.

2. Characterization of Highly Immunogenic p66/p51 as the Reverse Transcriptase of HTLV-III/LAV

3. Processing protease and reverse transcriptase from human immunodeficiency virus type I polyprotein in Escherichia coli