Synthesis and Structure–Activity Relationships of Pyrazolo[1,5-a]pyridine Derivatives: Potent and Orally Active Antagonists of Corticotropin-Releasing Factor 1 Receptor-Reference-Cited by-同舟云学术

Synthesis and Structure–Activity Relationships of Pyrazolo[1,5-a]pyridine Derivatives: Potent and Orally Active Antagonists of Corticotropin-Releasing Factor 1 Receptor

Published:2012-05-31 Issue:11 Volume:55 Page:5255-5269
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Takahashi Yoshinori¹,Hibi Shigeki¹,Hoshino Yorihisa¹,Kikuchi Koichi¹,Shin Kogyoku¹,Murata-Tai Kaoru¹,Fujisawa Masae¹,Ino Mitsuhiro¹,Shibata Hisashi¹,Yonaga Masahiro¹

Affiliation:

1. Medicinal Chemistry, ∥Biopharmacology, ‡Physical Chemistry, and §Drug Metabolism and Pharmacokinetics, Tsukuba Research Laboratories, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba-shi, Ibaraki 300-2635, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300259r

Reference36 articles.

1. Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin

2. Molecular Properties of the CRF Receptor

3. Expression cloning of a human corticotropin-releasing-factor receptor.

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