Near-Infrared Spectroscopy for In-Line Monitoring of Protein Unfolding and Its Interactions with Lyoprotectants during Freeze-Drying-Reference-Cited by-同舟云学术

Near-Infrared Spectroscopy for In-Line Monitoring of Protein Unfolding and Its Interactions with Lyoprotectants during Freeze-Drying

Published:2011-12-23 Issue:2 Volume:84 Page:947-955
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Pieters Sigrid¹,De Beer Thomas²,Kasper Julia Christina³,Boulpaep Dorien¹,Waszkiewicz Oliwia¹,Goodarzi Mohammad¹,Tistaert Christophe¹,Friess Wolfgang³,Remon Jean-Paul⁴,Vervaet Chris⁴,Vander Heyden Yvan¹

Affiliation:

1. Department of Analytical Chemistry and Pharmaceutical Technology, Center for Pharmaceutical Research, Free University of Brussels (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium

2. Laboratory of Pharmaceutical Process Analytical Technology, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium

3. Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians University, Butenandtstrasse 5, 81377 Munich, Germany

4. Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ac2022184

Reference42 articles.

1. Thermodynamic and dynamic factors involved in the stability of native protein structure in amorphous solids in relation to levels of hydration

2. Impact of critical process and formulation parameters affecting in‐process stability of lactate dehydrogenase during the secondary drying stage of lyophilization: A mini freeze dryer study