The Sugar Ring of the Nucleoside Is Required for Productive Substrate Positioning in the Active Site of Human Deoxycytidine Kinase (dCK): Implications for the Development of dCK-Activated Acyclic Guanine Analogues-Reference-Cited by-同舟云学术

The Sugar Ring of the Nucleoside Is Required for Productive Substrate Positioning in the Active Site of Human Deoxycytidine Kinase (dCK): Implications for the Development of dCK-Activated Acyclic Guanine Analogues

Published:2010-07-14 Issue:15 Volume:53 Page:5792-5800
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hazra Saugata¹,Konrad Manfred²,Lavie Arnon¹

Affiliation:

1. Department of Biochemistry and Molecular Genetics University of Illinois at Chicago, 900 South Ashland Avenue, Chicago, Illinois 60607

2. Max Planck Institute for Biophysical Chemistry, Am Fassberg 11 D-37077 Göttingen, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm1005379

Reference31 articles.

1. Structure and function of cellular deoxyribonucleoside kinases

2. Mammalian deoxyribonucleoside kinases

3. Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase

4. Nucleoside analogs: molecular mechanisms signaling cell death

5. Nucleoside analogues: mechanisms of drug resistance and reversal strategies

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