N-[6-(4-Butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a Novel Intravenous and Oral, Reversible, and Directly Acting P2Y12 Antagonist-Reference-Cited by-同舟云学术

N-[6-(4-Butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a Novel Intravenous and Oral, Reversible, and Directly Acting P2Y12 Antagonist

Published:2014-08-25 Issue:17 Volume:57 Page:7293-7316
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Boldron Christophe¹,Besse Angélina¹,Bordes Marie-Françoise¹,Tissandié Stéphanie¹,Yvon Xavier¹,Gau Benjamin¹,Badorc Alain¹,Rousseaux Tristan¹,Barré Guillaume¹,Meneyrol Jérôme¹,Zech Gernot²,Nazare Marc³,Fossey Valérie⁴,Pflieger Anne-Marie¹,Bonnet-Lignon Sandrine¹,Millet Laurence¹,Briot Christophe⁵,Dol Frédérique¹,Hérault Jean-Pascal¹,Savi Pierre¹,Lassalle Gilbert¹,Delesque Nathalie¹,Herbert Jean-Marc¹,Bono Françoise¹

Affiliation:

1. Sanofi R&D, 195 Route d’Espagne, 31036 Toulouse Cedex, France

2. Sanofi R&D, Industriepark Hoechst, 65926 Frankfurt am Main, Germany

3. AG Medizinische Chemie, Leibniz-Institut für Molekulare Pharmakologie, 13125 Berlin, Germany

4. Sanofi R&D, 1, Avenue Pierre Brossolette, 91385 Chilly-Mazarin Cedex, France

5. Sanofi R&D, 371 Rue du Professeur Joseph Blayac, 34184 Montpellier, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500588w