Characterization of Molecular Tweezer Binding on α-Synuclein with Native Top-Down Mass Spectrometry and Ion Mobility-Mass Spectrometry Reveals a Mechanism for Aggregation Inhibition

Author:

Lantz Carter1,Lopez Jaybree1,Goring Andrew K.1,Zenaidee Muhammad A.12ORCID,Biggs Karl3,Whitelegge Julian P.4ORCID,Ogorzalek Loo Rachel R.1ORCID,Klärner Frank-Gerrit5,Schrader Thomas5ORCID,Bitan Gal36ORCID,Loo Joseph A.167ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of California─Los Angeles, Los Angeles, California 90095, United States

2. Australian Proteome Analysis Facility, Macquarie University, Macquarie Park, New South Wales 2109, Australia

3. Department of Neurology and Brain Research Institute, David Geffen School of Medicine at UCLA, University of California─Los Angeles, Los Angeles, California 90095, United States

4. The Pasarow Mass Spectrometry Laboratory, The Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, University of California─Los Angeles, Los Angeles, California 90095, United States

5. Institute of Chemistry, University of Duisburg-Essen, Essen 45141, Germany

6. Molecular Biology Institute, University of California─Los Angeles, Los Angeles, California 90095, United States

7. Department of Biological Chemistry, David Geffen School of Medicine at UCLA, University of California─Los Angeles, Los Angeles, California 90095, United States

Funder

National Institute of Neurological Disorders and Stroke

National Center for Research Resources

Basic Energy Sciences

National Institute of Dental and Craniofacial Research

Binder Family Foundation

Office of the Director

National Institute of General Medical Sciences

Cure Sanfilippo Foundation

Publisher

American Chemical Society (ACS)

Subject

Spectroscopy,Structural Biology

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