Multi-Attribute Monitoring Method for Process Development of Engineered Antibody for Site-Specific Conjugation-Reference-Cited by-同舟云学术

Multi-Attribute Monitoring Method for Process Development of Engineered Antibody for Site-Specific Conjugation

Published:2023-06-02 Issue:7 Volume:34 Page:1330-1341
ISSN:1044-0305
Container-title:Journal of the American Society for Mass Spectrometry
language:en
Short-container-title:J. Am. Soc. Mass Spectrom.

Author:

Hines Alistair R.¹^ORCID,Edgeworth Matthew¹,Devine Paul W. A.¹,Shepherd Samuel¹,Chatterton Nicholas²,Turner Claire³,Lilley Kathryn S.⁴^ORCID,Chen Xiaoyu⁵,Bond Nicholas J.¹^ORCID

Affiliation:

1. Analytical Sciences, Biopharmaceutical Development R&D, AstraZeneca, Cambridge, CB2 0AA, United Kingdom

2. School of Life, Health and Chemical Sciences, The Open University, Walton Hall, Milton Keynes, MK7 6AA, United Kingdom

3. College of Health, Medicine & Life Sciences, Brunel University London, Middlesex, UB8 3PH, United Kingdom

4. Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QR, United Kingdom

5. Analytical Sciences, Biopharmaceutical Development, R&D, AstraZeneca, Gaithersburg, Maryland 20878, United States

Funder

AstraZeneca

Publisher

American Chemical Society (ACS)

Subject

Spectroscopy,Structural Biology

Link

https://pubs.acs.org/doi/pdf/10.1021/jasms.3c00037

Reference52 articles.

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2. Production Processes for Monoclonal Antibodies

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4. Heterogeneity of Monoclonal Antibodies

5. High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans

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