Cdc7 Kinase Inhibitors: 5-Heteroaryl-3-Carboxamido-2-Aryl Pyrroles as Potential Antitumor Agents. 1. Lead Finding

Author:

Menichincheri Maria1,Albanese Clara1,Alli Cristina1,Ballinari Dario1,Bargiotti Alberto1,Caldarelli Marina1,Ciavolella Antonella1,Cirla Alessandra1,Colombo Maristella1,Colotta Francesco1,Croci Valter1,D’Alessio Roberto1,D’Anello Matteo1,Ermoli Antonella1,Fiorentini Francesco2,Forte Barbara1,Galvani Arturo1,Giordano Patrizia1,Isacchi Antonella1,Martina Katia1,Molinari Antonio2,Moll Jürgen K.1,Montagnoli Alessia1,Orsini Paolo1,Orzi Fabrizio1,Pesenti Enrico1,Pillan Antonio1,Roletto Fulvia1,Scolaro Alessandra1,Tatò Marco1,Tibolla Marcellino1,Valsasina Barbara1,Varasi Mario1,Vianello Paola1,Volpi Daniele1,Santocanale Corrado1,Vanotti Ermes1

Affiliation:

1. Nerviano Medical Sciences Srl, Business Unit Oncology, Viale Pasteur 10, 20014 Nerviano (MI), Italy

2. Accelera Srl, Viale Pasteur 10, 20014 Nerviano (MI), Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference30 articles.

1. Chabner, B. A.; Ryan, D. P.; Paz-Arez, L.; Garcia-Carbonero, R.; Calabresi, P.The Pharmacological Basis of Therapeutics;McGraw-Hill:New York, 2001; Chapter 52, pp1389−1460.

2. Molecular mechanisms of drug resistance

3. DNA Replication in Eukaryotic Cells

4. Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication

5. Identification of Mcm2 Phosphorylation Sites by S-phase-regulating Kinases

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