1. Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan, Lead Chemical Co. Ltd, 77-3 Himata, Toyama 930-0192, Japan, and Graduate School of Science and Technology for Research, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan