1. Laboratoire de Chimie Organique, ESPCI ParisTech, CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France, Janssen Research & Development, Division of Janssen-Cilag S.A., Oncology and Medicinal Chemistry, Campus de Maigremont, 27106 Val de Reuil, Cedex, France, and Janssen Research & Development, Division of Janssen Pharmaceutica NV, Turnhoutsweg 30, 2340 Beerse, Belgium