Synthesis and Pharmacological Evaluation of a Selected Library of New Potential Anti-inflammatory Agents Bearing the γ-Hydroxybutenolide Scaffold: a New Class of Inhibitors of Prostanoid Production through the Selective Modulation of Microsomal Prostaglandin E Synthase-1 Expression-Reference-Cited by-同舟云学术

Synthesis and Pharmacological Evaluation of a Selected Library of New Potential Anti-inflammatory Agents Bearing the γ-Hydroxybutenolide Scaffold: a New Class of Inhibitors of Prostanoid Production through the Selective Modulation of Microsomal Prostaglandin E Synthase-1 Expression

Published:2007-04-04 Issue:9 Volume:50 Page:2176-2184
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Guerrero Maria D.¹,Aquino Maurizio¹,Bruno Ines¹,Terencio María C.¹,Paya Miguel¹,Riccio Raffaele¹,Gomez-Paloma Luigi¹

Affiliation:

1. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy, and Departamento de Farmacología, Facultad de Farmacia, Universidad de Valencia, Avenue Vicente Andrés Estellés s/n, 46100, Burjasot, Valencia, Spain

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0700823

Reference50 articles.

1. Petrosaspongiolides M−R: New Potent and Selective Phospholipase A2 Inhibitors from the New Caledonian Marine Sponge Petrosaspongia nigra

2. Inhibition of the NF-κB signaling pathway mediates the anti-inflammatory effects of petrosaspongiolide M

3. Molecular Basis of Phospholipase A2 Inhibition by Petrosaspongiolide M

4. Further insights on the structural aspects of PLA2 inhibition by γ-hydroxybutenolide-containing natural products: a comparative study on petrosaspongiolides M–R

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