PEGylated Nanoparticles Bind to and Alter Amyloid-Beta Peptide Conformation: Toward Engineering of Functional Nanomedicines for Alzheimer’s Disease

Author:

Brambilla Davide1,Verpillot Romain1,Le Droumaguet Benjamin1,Nicolas Julien1,Taverna Myriam1,Kóňa Juraj2,Lettiero Barbara3,Hashemi S. Hossein3,De Kimpe Line4,Canovi Mara5,Gobbi Marco5,Nicolas Valérie6,Scheper Wiep4,Moghimi S. Moein37,Tvaroška Igor2,Couvreur Patrick1,Andrieux Karine1

Affiliation:

1. Laboratoire de Physico-Chimie, Pharmacotechnie et Biopharmacie, UMR CNRS 8612, Univ Paris-Sud 11, Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, F-92296 Chatenay-Malabry, France

2. Institute of Chemistry, Center for Glycomics, Slovak Academy of Sciences, Dúbravska cesta 9, 845 38 Bratislava, Slovakia

3. Nanomedicine Laboratory, Centre for Pharmaceutical Nanotechnology and Nanotoxicology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark

4. Department of Genome Analysis, Academic Medical Center, University of Amsterdam, 1012 WX Amsterdam, The Netherlands

5. Istituto di Ricerche Farmacologiche “Mario Negri”, 20156 Milano, Italy

6. Institut d’Innovation Thérapeutique (IFR141 ITFM), Univ Paris-Sud, Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, F-92296 Châtenay-Malabry, France

7. NanoScience Centre, University of Copenhagen, DK-2100 Copenhagen Ø, Denmark

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

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