2-Aminopyridines as Highly Selective Inducible Nitric Oxide Synthase Inhibitors. Differential Binding Modes Dependent on Nitrogen Substitution-Reference-Cited by-同舟云学术

2-Aminopyridines as Highly Selective Inducible Nitric Oxide Synthase Inhibitors. Differential Binding Modes Dependent on Nitrogen Substitution

Published:2004-05-07 Issue:12 Volume:47 Page:3320-3323
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Connolly Stephen¹,Aberg Anders¹,Arvai Andrew¹,Beaton Haydn G.¹,Cheshire David R.¹,Cook Anthony R.¹,Cooper Sally¹,Cox David¹,Hamley Peter¹,Mallinder Phil¹,Millichip Ian¹,Nicholls David J.¹,Rosenfeld Robin J.¹,St-Gallay Stephen A.¹,Tainer John¹,Tinker Alan C.¹,Wallace Alan V.¹

Affiliation:

1. Medicinal Chemistry, Discovery BioScience, Molecular Biology and Physical and Metabolic Sciences Departments, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, Leics LE11 5RH, U.K., AstraZeneca Structural Chemistry Laboratory, AstraZeneca R&D Mölndal, 431 83 Mölndal, Sweden, and Department of Molecular Biology and Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, San Diego, California 92037

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm031035n

Reference16 articles.

1. Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation

2. L-N6-(1-Iminoethyl)lysine: A Selective Inhibitor of Inducible Nitric Oxide Synthase

3. A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics

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