Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition-Reference-Cited by-同舟云学术

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Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition

Published:2012-07-30 Issue:31 Volume:51 Page:6114-6126
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Holzapfel Genevieve¹,Buhrman Greg¹,Mattos Carla¹²

Affiliation:

1. Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, United States

2. Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi300509j

Reference60 articles.

1. The GTPase superfamily: a conserved switch for diverse cell functions

2. The GTPase superfamily: conserved structure and molecular mechanism

3. The dark side of Ras: regulation of apoptosis

4. Ras oncogenes: split personalities

5. Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase

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