1. Laboratory of Pharmacology, Chulabhorn Research Institute (CRI), Vibhavadee-Rangsit Highway, Laksi, Bangkok 10210, Thailand, Faculty of Pharmacy, Srinakharinwirot University, Rangsit-Nakhonnayok Road, Nakhonnayok 26120, Thailand, and Department of Pharmacology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand