Complex Polyfluoride Additives in Fmoc-Amino Acid Fluoride Coupling Processes. Enhanced Reactivity and Avoidance of Stereomutation-Reference-Cited by-同舟云学术

Complex Polyfluoride Additives in Fmoc-Amino Acid Fluoride Coupling Processes. Enhanced Reactivity and Avoidance of Stereomutation

Published:2003-03-05 Issue:7 Volume:5 Page:975-977
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Carpino Louis A.¹,Ionescu Dumitru¹,El-Faham Ayman¹,Beyermann Michael¹,Henklein Peter¹,Hanay Christiane¹,Wenschuh Holger¹,Bienert Michael¹

Affiliation:

1. Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, Institute of Molecular Pharmacology, Robert-Rössle-Str. 10, 13125 Berlin, Germany, Institut für Biochemie, Humboldt-Universität, Monbijoustr. 2, 10117 Berlin, Germany, and Jerini AG, Invalidenstr. 130, 10115 Berlin, Germany

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ol020235a

Reference22 articles.

1. [(9-Fluorenylmethyl)oxy]carbonyl (FMOC) amino acid fluorides. Convienient new peptide coupling reagents applicable to the FMOC/tert-butyl strategy for solution and solid-phase syntheses.

2. tert-Butyloxycarbonyl and benzyloxycarbonyl amino acid fluorides. New, stable rapid-acting acylating agents for peptide synthesis

3. Synthesis of Fmoc-amino acid fluorides via DAST, an alternative fluorinating agent

4. Peptide Synthesis via Amino Acid Halides

5. Tetramethylfluoroformamidinium Hexafluorophosphate: A Rapid-Acting Peptide Coupling Reagent for Solution and Solid Phase Peptide Synthesis

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