Comparative Hydrogen–Deuterium Exchange for a Mesophilic vs Thermophilic Dihydrofolate Reductase at 25 °C: Identification of a Single Active Site Region with Enhanced Flexibility in the Mesophilic Protein-Reference-Cited by-同舟云学术

Comparative Hydrogen–Deuterium Exchange for a Mesophilic vs Thermophilic Dihydrofolate Reductase at 25 °C: Identification of a Single Active Site Region with Enhanced Flexibility in the Mesophilic Protein

Published:2011-08-30 Issue:38 Volume:50 Page:8251-8260
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Oyeyemi Olayinka A.¹,Sours Kevin M.²,Lee Thomas²,Kohen Amnon³,Resing Katheryn A.²,Ahn Natalie G.²⁴,Klinman Judith P.¹

Affiliation:

1. Department of Chemistry, Department of Molecular and Cell Biology, and the California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, California 94720, United States

2. Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, United States

3. Department of Chemistry, The University of Iowa, Iowa City, Iowa 52242, United States

4. Howard Hughes Medical Institute, University of Colorado, Boulder, Colorado 80309, United States

Funder

Bloom's Syndrome Foundation

National Institutes of Health

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

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