The Bioactive Conformation of Aminoalkylindoles at the Cannabinoid CB1 and CB2 Receptors: Insights Gained from (E)- and (Z)-Naphthylidene Indenes-Reference-Cited by-同舟云学术

The Bioactive Conformation of Aminoalkylindoles at the Cannabinoid CB1 and CB2 Receptors: Insights Gained from (E)- and (Z)-Naphthylidene Indenes

Published:1998-12-01 Issue:26 Volume:41 Page:5177-5187
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Reggio Patricia H.¹,Basu-Dutt Sharmista¹,Barnett-Norris Judy¹,Castro Marie T.¹,Hurst Dow P.¹,Seltzman Herbert H.¹,Roche Michael J.¹,Gilliam Anne F.¹,Thomas Brian F.¹,Stevenson L. A.¹,Pertwee Roger G.¹,Abood Mary E.¹

Affiliation:

1. Department of Chemistry, Kennesaw State University, Kennesaw, Georgia 30144, Department of Chemistry, State University of West Georgia, Carrolton, Georgia 30118, Research Triangle Institute, Research Triangle Park, North Carolina 27709-2194, Department of Biomedical Sciences, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen AB25 2ZD, Scotland, United Kingdom, and Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond,...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9801197

Reference20 articles.

1. Conformationally restrained analogs of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor

2. Aminoalkylindoles: Structure-Activity Relationships of Novel Cannabinoid Mimetics

3. Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and .beta.-lactamase stability on the pKa of the C-7 heterocycle

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