Oxidative DNA Damage Induced by Benz[a]anthracene Dihydrodiols in the Presence of Dihydrodiol Dehydrogenase

Author:

Seike Kazuharu1,Murata Mariko1,Hirakawa Kazutaka1,Deyashiki Yoshihiro1,Kawanishi Shosuke1

Affiliation:

1. Department of Environmental and Molecular Medicine, Mie University School of Medicine, and Department of Radiation Chemistry, Life Science Research Center, Mie University, Tsu, Mie 514-8507, Japan, and Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu 502-8585, Japan

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Reference22 articles.

1. Yu, D., Berlin, J. A., Penning, T. M., and Field, J. (2002) Reactive oxygen species generated by PAH o-quinones cause change-in-function mutations in p53.Chem. Res. Toxicol. 15, 832−842.

2. IARC Working Group (1983) General remarks. IARC monographs on the evaluation of the carcinogenic risk of chemicals to human.Polynuclear Aromatic Compounds, Part 1, Vol. 32, pp 33−91, IARC, Lyon.

3. Tobacco Smoke Carcinogens and Lung Cancer

4. IARC Working Group (1973) Benz[a]anthracene. IARC monographs on the evolution of the carcinogenic risk of chemicals to human.Certain Polycyclic Aromatic Hydrocarbons and Heterocyclic Compounds, Vol. 3, p 45, IARC, Lyon.

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