1. Institute of Biomaterials and Biomedical Engineering, Faculty of Dentistry, University of Toronto, 124 Edward Street, Room 461, Toronto, Ontario, Canada, M5G1G6, Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Room 555, Ottawa, Ontario, Canada, K1Y4W7, and Institute of Biomaterials and Biomedical Engineering, Faculty of Dentistry, University of Toronto, 124 Edward Street, Room 464D, Toronto, Ontario, Canada, M5G1G6