1. School of Chemistry, University of Southampton, Southampton, HANTS, SO17 1BJ, U.K., Molecular Discovery Research, GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709-3398, and Cardiovascular & Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline, 25 Avenue du Quebec, 91951 Les Ulis, France