Diastereoselective Aldol Reaction of Zincated 3-Chloro-3-methyl-1-azaallylic Anions as Key Step in the Synthesis of 1,2,3,4-Tetrasubstituted 3-Chloroazetidines

Author:

Mangelinckx Sven1,De Sterck Bart2,Colpaert Filip1,Catak Saron2,Jacobs Jan1,Rooryck Stijn1,Waroquier Michel2,Van Speybroeck Veronique2,De Kimpe Norbert1

Affiliation:

1. Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium

2. Center for Molecular Modeling, Ghent University, Technologiepark 903, B-9052 Zwijnaarde, Belgium, Member of QCMM Alliance Ghent-Brussels

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Reference93 articles.

1. The azetidines. Recent synthetic developments

2. bMoore, J. A.; Ayers, R. S.InChemistry of Heterocyclic Compounds–small Ring Heterocycles;Hassner, A., Ed.Wiley:New York, 1983; Part 2, pp1–217.

3. cDavies, D. E.; Starr, R. C.InComprehensive Heterocyclic Chemistry;Lwowski, W., Ed.Pregamon:Oxford, 1984; Vol.7,Part 5, pp237–284.

4. eSingh, G. S.; D’hooghe, M.; De Kimpe, N.InComprehensive Heterocyclic Chemistry III;Katritzky, A.; Ramsden, C.; Scriven, E.; Taylor, R., Eds.Elsevier:Oxford, 2008; Vol.1, p1.

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